Screen-detected vs symptomatic breast cancer: is improved survival due to stage migration alone?
G C Wishart, D C Greenberg, P D Britton, P Chou, C H Brown, A D Purushotham & S W Duffy
British Journal of Cancer (2008) 98, 1741-1744
Link to Journal
An interesting paper from Cambridge. The authors suggest that tumours picked up at screening are biologically different enough that current methods for estimating prognosis and therefore treatment, overestimate the benefit of systemic treatments in screen-detected cancers and lead to overtreatment of these patients.
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