Combined Screening With Ultrasound and Mammography vs Mammography Alone in Women at Elevated Risk of Breast Cancer
Wendie A. Berg; Jeffrey D. Blume; Jean B. Cormack; Ellen B. Mendelson; Daniel Lehrer; Marcela Bohm-Velez; Etta D. Pisano; Roberta A. Jong; W. Phil Evans; Marilyn J. Morton; Mary C. Mahoney; Linda Hovanessian Larsen; Richard G. Barr; Dione M. Farria; Helga S. Marques; Karan Boparai; for the ACRIN 6666 Investigators
JAMA 2008;299 2151-2163
Link to Journal
Adding a single screening ultrasound to mammography will yield an additional 1.1 to 7.2 cancers per 1000 high-risk women, but it will also substantially increase the number of false positives.
Results of the ACRIN 6666 trial, whose results were presented at RSNA 2007. As expected ultrasound is good at picking up additional cancers, not visualized on mammography, BUT at a significant cost of false positivies and unnecessary biopsies.
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