US-guided diffused optical tomography: a promising functional imaging technique in breast lesions

US-guided diffused optical tomography: a promising functional imaging technique in breast lesions
Shan-Shan You, Yu-Xin Jiang, Qing-Li Zhu, Ji-Bin Liu, Jing Zhang, Qing Dai, He Liu & Qiang Sun
Eur Radiol 2010 20;2:293-302

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Results:  There were 96 benign lesions and 118 malignant lesions. The total haemoglobin concentration (THC) of all 214 lesions was calculated from DOT. The average THC in benign lesions was 125.5 ± 83.4 µmol/L, and in malignant lesions 222.2 ± 87.2 µmol/L. The THC of malignant lesions was significantly higher than that of benign lesions (p < 0.05). 

When a THC of 140 µmol/L was used as the cutoff value for differentiating breast cancer from benign lesions, the sensitivity, specificity, accuracy, positive predictive value and negative predictive value of DOT were 83.9%, 66.7%, 76.2%, 75.6% and 77.1%, respectively. 

Our study demonstrated that THC was significantly higher in malignant lesions than in benign lesions.
 
Conclusion:  US-guided diffused optical tomography, a noninvasive functional imaging technique, has potential utility in differentiating breast cancer from benign lesions