RECIST revised: implications for the radiologist. A review article on the modified RECIST guideline

RECIST revised: implications for the radiologist. A review article on the modified RECIST guideline
Els L. van Persijn van Meerten, Hans Gelderblom & Johan L. Bloem
Eur Radiol (2010) 20: 1456–1467

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The purpose of this review article is to familiarize radiologists with the recently revised Response Evaluation Criteria in Solid Tumours (RECIST), used in many anticancer drug trials to assess response and progression rate. 

The most important modifications are: a reduction in the maximum number of target lesions from ten to five, with a maximum of two per organ, with a longest diameter of at least 10 mm; 

In lymph nodes (LNs) the short axis rather than the long axis should be measured, with normal LN measuring <10 mm, non- target LN ≥10 mm but <15 mm and target LN ≥15 mm; 

Osteolytic lesions with a soft tissue component and cystic tumours may serve as target lesions;

An additional requirement for progressive disease (PD) of target lesions is not only a ≥20% increase in the sum of the longest diameter (SLD) from the nadir but also a ≥5 mm absolute increase in the SLD (the other response categories of target lesion are unchanged); 

PD of non-target lesions can only be applied if the increase in non-target lesions is representative of change in overall tumour burden; detailed imaging guidelines

Contrast-enhanced ultrasound in the characterisation of breast masses: utility of quantitative analysis in comparison with MRI

Contrast-enhanced ultrasound in the characterisation of breast masses: utility of quantitative analysis in comparison with MRI
Natalia Caproni, Francesca Marchisio, Annarita Pecchi, Barbara Canossi, Rachele Battista, Piero D’Alimonte & Pietro Torricelli
Eur Radiol (2010) 20: 1384–1395
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CE-US quantitative analysis offers an objective and reproducible assessment of lesion vascularisation, with good correlation with the results of MRI